"The central air conditioning system in pharmaceutical factory has been in need of updating and upgrading!" China industry economy Federation of ozone, director of professional committee of aging recently when accepting a reporter to interview pointed out that in recent years, due to the ozone equipment manufacturers were vicious price competition, resulting in a decline in the performance of the products, and in the pharmaceutical industry has been widely used built-in ozone disinfection equipment maintenance and difficult to detect, and many other issues. Therefore, equipment renewal, and regulate the use and validation, has become the key issues on the pharmaceutical application of ozone disinfection field needs to be solved urgently. Li Hanzhong said that in the face of these urgent problems, China Industrial Economic Association of ozone Specialized Committee will spare no effort to carry out cooperation with pharmaceutical companies to provide technical support.
The problem - built-in equipment outstanding
It is understood, since the 90s of the last century, the pharmaceutical industry in the implementation of GMP certification, ozone technology began in pharmaceutical air purification disinfection of the area. Zhenjiang of Jiangsu koner ozone company is a pioneer, they in cooperation with related departments, first developed in the for HVAC system of central air conditioner disinfection and purification by using the built-in ozone equipment, and created a is arranged on the gas pipeline design generator connector body modification model, solve the problem of system and disinfection of space. However, due to the low technical content of ozone equipment, a large number of small ozone production enterprises in the end of 1990s. They and purification company to the pharmaceutical factory to promote cheap central air conditioning system with built-in ozone equipment, which leads to product indicators can not be detected, performance and other serious problems to reduce the problem.
The methods of producing ozone by means of chemical method, electrochemical method, corona discharge method and so on. Industrial applications of the vast majority of ozone equipment is the lowest energy consumption of corona discharge technology, that is, oxygen containing gases in the alternating high-voltage electric field generated corona discharge, O2 decomposition and polymerization into O3.
Director Li Hanzhong told reporters, for air purification systems and space disinfection, the requirements of a reasonable configuration of certain specifications of the ozone generator. At present in the pharmaceutical factory HVAC central air conditioning system for the installation of the generator has a built-in and external two. At present, there are three main problems in the application of the built-in ozone system. One is that the ozone generator is all along the surface discharge type, most of the glass pipe network with inert gas is used to discharge the ozone pipe. The ozone device in a foreign country is called the ozone lamps, foreign production of this kind of generator is generally installed in the refrigerated food on board to food mildew preservation. Production of these devices began in China in the 1980s, but due process is not strict, there is shortcoming of ozone generating capacity fast decay, after the use of ozone generating capacity will less and less, the disinfection effect is very poor, short service life. However, due to its simple production, low price, so the pharmaceutical factory air disinfection equipment manufacturers are still in order to carry out low-cost competition. Two is a built-in generator without air source, by the pipeline to send the wind to take away the ozone, the ozone change factors are difficult to measure, manufacturers are only to estimate the yield, design parameters are difficult to ensure. Three is due to the influence of humidity and dust, ozone has increased to reduce, and likely to cause ignition brand filter material, in order to cause the accident. It is difficult to maintain and repair the generator.
- perfect external type generator
According to Li Hanzhong high workers, external ozone generator is a standard type of generator products, in line with the relevant national industry standards. The generator is configured with air drying and purification system, ozone generation chamber, cooling system, power supply and control protection system. The ozone quantity can be measured accurately. In the use, the standard generator can be placed in the air conditioning room, the ozone with the output pipe is introduced into the main supply channel, with the wind through the disinfection of space, so as to achieve the specific disinfection effect. The control system of the generator can be connected with the air conditioner unit, and the control system can also be used with a plurality of air conditioning units, and the control system of the generator can be controlled by the electromagnetic valve. Aging director stressed that although the price of external generator is much higher than the built-in type, but its reliable performance, stable disinfection effect and long service life, to meet the requirements of the pharmaceutical process of sterilization is absolutely necessary."Demand is difficult to accurately quantify ozone
According to the director of the aging, pharmaceutical factory use central air conditioning system for air purification and disinfection treatment, the ozone need including filling air supply duct volume and workshop space volume of the amount of ozone, a positive pressure leakage and natural decomposition. So far, due to the half-life of the ozone is difficult to determine, the central air-conditioning fresh air supply changes in large and other reasons, it is difficult to accurately quantify the amount of ozone. At present, the reference of foreign food processing workshop disinfection of the recommended amount and the domestic pharmaceutical enterprises experience, according to Q0=2.5 * C0 x V calculated ozone output (Q0 for the need of ozone generating capacity unit for g / h; ozone concentration C0 for the disinfection of space requirements of the unit for mg / cubic meters; V is the workshop space volume and air supply duct volume and units of cubic meters).
Key parameters - control
After the ozone generator is put into use, the disinfection process parameters should be determined: ozone concentration, disinfection time, temperature, humidity. Ozone concentration should be monitored regularly in daily operation. Ozone air disinfection of the main parameters of concentration (C) and time of action (T), the effect of disinfection K=Ct. Ambient conditions are temperature and humidity. Li Hanzhong director told reporters, in the disinfection time and temperature, humidity is approximately the same conditions, the ozone concentration and disinfection effect of the corresponding relationship. In the past, due to lack of appropriate instruments and lack of means, supply manufacturers and users are rarely detected in the field of space ozone concentration. Many use units are directly collected bacteria samples to determine the effect of disinfection, it is difficult to identify the exact cause of failure. Now determination method of ozone concentration many portable instrumentation for in field detection space ozone concentrations of an ozone monitor of New Zealand aeroQUAL company the timely indicator concentration value, and has an interface capable of online drawn curve. Ozone generator at the time of acceptance should be tested for its ozone concentration and production, determine whether qualified. According to reports, the practical application shows that at room temperature, the relative humidity (RH) in more than 70% of the disinfection effect is better. The HVAC gas supply system for pharmaceutical companies with good purification conditions, under normal temperature and RH70% conditions, 10 mg / cubic meter of ozone concentration and 60 minutes of disinfection time, can reach the requirements of million clean degree of disinfection. The standard requirements of the hundred level can improve the ozone concentration or prolong the disinfection time.
- effect detection should avoid the influence of organic substance
In an interview, director of the aging emphasized that due to ozone oxidation properties of killing microorganisms. Therefore, detection and verification of its germicidal efficacy and other disinfectants differ, in practice should be paid attention to. For example, bacteria in the air sampling air impact sampling method and the plate sedimentation, technical personnel should be before and after disinfection of samples, to determine the bactericidal rate and the presence of bacteria. The impact of sampling and sampling as well, Petri dishes are used when the wind stops blowing.
Worthy of discussion, currently Pharmaceutical General disinfection effect of verification method will test strains of bacteria suspension directly coated on culture Geikie, verify the effect. In this regard, the aging director pointed out that due to actual bacteria have been cultured based organic infiltration, disinfection ozone firstly and organic contact oxidation reaction and be consumed quickly, so its role and bacteria in a contact oxidation greatly reduced, which is the main reason resulting in the detection results were not very satisfactory. This experimental bacteria made saline bacteria suspension (without interference agent), direct spray in the space or into Petri dishes, in a Petri dish in the uniform diffusion film, and ozone sterilization, by cultivating the germicidal efficacy of detecting and identifying the corresponding to the ozone concentration and sterilization time. This method can avoid the effect of organic compounds on the germicidal efficacy. |
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